REPROCELL Inc. was established in 2003 by leading Japanese university researchers. The company quickly became a pioneer in stem cell research, notably providing products employed by Nobel Laureate Professor Shinya Yamanaka during his groundbreaking work on induced pluripotent stem cell (iPSC) technologies at Kyoto University. REPROCELL was the first company to offer iPSC-derived human cardiomyocytes, hepatocytes, and neuronal cells for research applications. In 2013, the company was listed on the Japan JASDAQ / Growth stock market
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Headquartered in Yokohama, Japan, REPROCELL operates globally with facilities in the United States, Europe, and India. The company serves a diverse clientele, including pharmaceutical and biotechnology companies, academic institutions, and research organisations, providing them with advanced tools and services to accelerate drug discovery and development processes.

Key Products and Services

Clinical Stem Cell Services

• GMP iPSC Production Service: Generation of clinical-grade iPSCs using proprietary RNA reprogramming technology.
• GMP iMSC & MSC Production Service: Production of mesenchymal stem cells (MSCs) and induced MSCs (iMSCs) under Good Manufacturing Practice (GMP) conditions.
• GMP iPSC & iMSC Master Cell Bank (MCB) Manufacturing: Establishment of master cell banks for clinical applications.
• Ready-to-use GMP MSCs: Off-the-shelf MSCs prepared in compliance with GMP standards.

Research Stem Cell Services

• Donor Recruitment and Patient-Derived Cells: Sourcing of ethically consented human tissue samples.
• Target Cell Isolation: Isolation of specific cell types from human tissues.
• iPSC Reprogramming Service: Conversion of somatic cells into iPSCs using RNA-based methods.
• iPSC Expansion, Characterization, and Banking: Cultivation and quality control of iPSCs.
• Neuronal Differentiation Services: Differentiation of iPSCs into neuronal lineages for research purposes.
• Off-the-shelf Human iPSC Lines: Ready-made iPSC lines for various research applications.
• MSC Research Products: Tools and reagents for MSC-related research.

Gene Editing Services

• StemEdit Clinical Gene Editing: Utilisation of CRISPR-SNIPER technology for precise gene editing in clinical applications.

Drug Discovery and Preclinical Services

• Preclinical & Drug Discovery CRO: Contract research organisation services for preclinical drug development using human fresh tissue testing.
• NeoSight – Neoantigen Detection Service: Comprehensive neoantigen discovery platform for immuno-oncology research and early-phase clinical development.

Analytical and Genomic Services

• Clinical Laboratory Services: Comprehensive, personalised solutions for clinical research.
• Human Tissue Samples: Quality biospecimens linked to detailed clinical and demographic data.
• Genomic Services: Intensive customer service from assay design to data delivery.

REPROCELL Inc. stands at the forefront of stem cell research and regenerative medicine, offering a broad spectrum of services that bridge the gap between basic research and clinical application. With its commitment to innovation and quality, the company continues to support the global scientific community in advancing therapeutic solutions. Through its comprehensive suite of services, REPROCELL plays a pivotal role in accelerating the development of stem cell-based therapies, contributing to the evolution of precision medicine worldwide.