NHS Blood and Transplant

NHS Blood and Transplant Contract Manufacturing & Development (CDMO) Profile

Overview of Services

At NHS Blood and Transplant, we specialize in developing and manufacturing advanced therapy medicinal products (ATMPs) and provide extensive support for cell and gene therapies. Our services cater to healthcare, academic, and commercial clients, ensuring the highest quality standards through our MHRA-licensed laboratories and robust quality management system.

1) GMP Cell Manufacturing

We leverage our expertise to develop and manufacture ATMPs for research, pre-clinical, and clinical campaigns. Our services include:

-Translating research protocols into GMP-compliant procedures

-Process development and technology transfer to GMP

-Manufacturing, storage, and logistical support

-Product release by Qualified Persons (QPs)

2) DNA and Vector Manufacturing

The Clinical Biotechnology Centre (CBC) has over 20 years of experience in manufacturing molecular therapies, including:

-DNA plasmids and recombinant proteins

-Viral vectors (lentiviral and adeno-associated viral)

-Aseptic fill and finish, quality control testing, master cell banking, and process development

Stem Cell Services

Supporting haematopoietic stem cell transplantation through:

-Therapeutic Apheresis Services (TAS) for stem cell collections

-Stem Cell Immunotherapy (SCI) laboratories for processing services

-NHS Cord Blood Bank and British Bone Marrow Registry (BBMR) for collection and administration

Our comprehensive range of stem cell services includes:

-Apheresis collection, processing, and cryopreservation of stem cells

-Collection and storage of CAR-T cells (manufactured by third parties)

-Directed cord blood collection and banking

-Quality assurance and registry services

ATMP Storage and Distribution

We ensure the integrity and timely delivery of cell therapy products through:

-Expertise in cryopreservation and logistics

-Robust networks for transporting fresh or frozen products

-24/7 monitored vapour phase liquid nitrogen storage tanks

-Dedicated quality assurance teams

-HTA licences and JACIE accreditation for our laboratories

Our strong connections with hospitals and clinicians allow seamless support for cell therapy clinical trials and commissioned CAR-T cell therapies, usually without the need for additional contracts.

CDMO Services:
Cell & Gene Therapy Drug Substance Manufacturing (API); Clinical Trials materials and logistics; Packaging; Regulatory Services; Analytical Development Blow-Fill-Seal (BFS); Cartridges; Inhalers; Liquids; Lyophilized amps/vials; Pre-Filled Syringes (PFS); Semi-solids; Soft Gels; Solids; Sterile Ampoules; Sterile Vials

Year Founded:

Head Office: Solihull, United Kingdom

Number of Facilities: 3-5

Facility locations: Europe

Website: Visit the NHS Blood and Transplant website

Linkedin: Connect on Linkedin

Current Capacity: We have recently expanded our capacity for services across all our segments and are able to support potential partners for all their requirements for manufacturing molecular and cellular therapies.