Bespak, MEU, and H&T Presspart Collaborate for Low GWP Inhalers

• Bespak has announced partnerships with The Medicines Evaluation Unit (MEU) and H&T Presspart.

• The collaborations aim to accelerate the transition from existing pMDI formulations to more climate-friendly alternatives using low GWP propellants.

Bespak, a contract development and manufacturing organisation (CDMO) specialising in orally inhaled and nasal drug-device combination products, has announced new collaborations with The Medicines Evaluation Unit (MEU) and H&T Presspart. These partnerships are aimed at accelerating the industry’s transition from existing pressurised Metered Dose Inhaler (pMDI) formulations to more climate-friendly alternatives utilising low global warming potential (GWP) propellants.

The partnership with the MEU, one of the UK’s leading contract research organisations, will align expert teams from both organisations. They will share knowledge and combine resources to fast-track time to clinic and increase the throughput of low GWP pMDIs moving through clinical evaluation. This collaboration is designed to service the increasing demand from pharmaceutical companies transitioning their inhaler portfolios to utilise the new generation of greener propellants.

“Bespak’s clinical supply capabilities at its Holmes Chapel site will manufacture pMDIs containing the new propellants (HFA-152a and HFO-1234ze), for use in clinical studies to be conducted at the MEU,” the press release stated. The collaboration also includes MEU’s Regulatory consultancy for clients to access as part of a package of services.

Meanwhile, Bespak and H&T Presspart, a leader in the development, manufacturing and supply of inhaled drug delivery components and devices, aim to bring rapid access to small-scale filling capabilities in GMP conditions. This will support development programs and clinical trials with both HFA-152a and HFO-1234ze propellants.

The collaboration leverages H&T Presspart’s expertise in inhalation product development, the company’s low GWP filling equipment and market-leading portfolio of componentry, and Bespak’s expertise and leading position in valves. It also utilises Bespak’s formulation development expertise and finished product manufacturing capability. The partnership will accelerate industry understanding and customer success in the reformulation and commercialisation of products with a significantly lower environmental footprint.