Creative Biostructure Partners With High Q Technologies to Bring Quantum EPR Spectroscopy to Structural Biology CRO Services

• Creative Biostructure, a structural biology CRO offering cryo-EM, NMR spectroscopy, X-ray crystallography, and structure-based drug discovery support, has announced a strategic partnership with High Q Technologies to provide scientific consultation, experimental design support, and workflow guidance for organizations implementing the FATHOM® EPR spectroscopy platform.

• The collaboration is designed to expand access to quantum-enabled electron paramagnetic resonance (EPR) spectroscopy for pharmaceutical and biotechnology sponsors studying disordered, flexible, and dynamically complex protein systems that cannot be fully characterized through static structural methods alone.

Creative Biostructure, a structural biology contract research organization, and High Q Technologies, a developer of quantum-enabled electron paramagnetic resonance (EPR) spectroscopy systems, announced a strategic partnership on June 2, 2026, to expand adoption of EPR spectroscopy within pharmaceutical and biotechnology drug discovery workflows. Under the collaboration, Creative Biostructure will provide scientific consultation, experimental design support, and workflow guidance for organizations implementing High Q Technologies’ FATHOM® EPR spectroscopy platform.

The partnership addresses a recognized gap in structural biology CRO services. EPR spectroscopy is an established technique for studying protein dynamics, long-range distance measurements, and molecular motion — capabilities that are increasingly relevant as drug discovery programs target intrinsically disordered proteins, conformational intermediates, and dynamic biomolecular systems implicated in oncology, neurodegeneration, and other complex disease areas. Despite its scientific value, broad adoption of conventional EPR has been constrained by instrument complexity, demanding workflow requirements, and the need for specialized technical expertise in experimental design and data interpretation. High Q Technologies’ FATHOM® platform addresses these barriers through quantum sensor technology that simplifies the measurement workflow while extending the range and sensitivity of EPR-based protein dynamics analysis.

For sponsors and research organizations working with Creative Biostructure’s existing structural biology CRO portfolio — which spans cryo-EM, NMR spectroscopy, X-ray crystallography, and membrane protein characterization — the addition of FATHOM® EPR introduces a complementary dynamic layer to an otherwise predominantly static set of structural characterization tools. EPR’s ability to probe conformational ensembles and molecular motion fills a specific analytical gap between static structure determination and fully computational approaches, supporting more complete mechanistic understanding of drug:target interactions for sponsors engaged in structure-based drug discovery.

The collaboration reflects a broader trend in structural biology CRO services toward integrative approaches that combine multiple complementary techniques within a single outsourced workflow. Cryo-EM and NMR provide high-resolution structural snapshots; EPR adds temporal and dynamic information that neither method fully captures. Together, the combined toolkit supports sponsors pursuing targets where conformational flexibility, disorder, or dynamic intermediates are central to therapeutic mechanism — a category that increasingly includes some of the most commercially and scientifically significant targets in biopharma pipelines.

“Modern structural biology is moving towards integrating synergistic techniques to understand complex biomolecular systems. EPR spectroscopy adds an important layer of dynamic information that complements methods such as cryo-EM, NMR spectroscopy, and computational modeling.”

Tony Zhang, Principal Scientist, Creative Biostructure