- Indena and TCG GreenChem have entered a strategic collaboration to accelerate the development of innovative payload-linkers for Antibody-Drug Conjugates (ADCs).
- The partnership combines Indena’s capabilities in high-potent APIs with TCG GreenChem’s expertise in green chemistry and process intensification.
Indena and TCG GreenChem have announced a new strategic partnership aimed at advancing payload-linker development, a key component of Antibody-Drug Conjugates (ADCs).
Indena, headquartered in Italy, specialises in the development and production of active pharmaceutical ingredients (APIs) and highly potent APIs (HPAPIs) through plant extraction, synthesis, and precision fermentation. Its expertise in high-containment development and production underpins its role in ADC payload manufacturing. TCG GreenChem, based in Princeton, NJ, is a contract research, development, and manufacturing organisation (CRDMO) with a focus on catalysis, flow chemistry, biocatalysis, and data-driven pharmaceutical process design.
The companies aim to integrate their strengths in high containment and rapid process R&D to provide ADC developers with faster and more efficient routes to clinical and commercial supply. The first milestone of the collaboration will be a novel payload–linker designed to demonstrate how the approach can reduce development timelines and support patient access.
Daniele Giavini, Managing Director at Indena, said: “Partnering with TCG GreenChem means working with an authoritative partner to address the needs of ADCs developers. Our expertise in high containment processes, designed to produce innovative HPAPIs, complements their deep capability in complex chemistry and process intensification, managed with a green approach.”
The collaboration comes as the global ADC pipeline continues to expand. By mid-2025, over 180 companies were developing more than 1,170 ADC candidates, driving demand for contract manufacturing capacity and accelerated timelines. The partners also emphasised their commitment to sustainability, highlighting green chemistry, renewable energy, waste reduction, and circular economy initiatives as part of their model.
