The United States is global powerhouse in pharmaceutical contract development and manufacturing, home to some of the world’s most advanced CDMOs. The U.S. combines scale, scientific leadership, and advanced regulatory infrastructure to support drug development from early-stage innovation to commercial manufacturing.
The U.S. currently leads biomedical research globally, conducting roughly 46% of all life‑sciences R&D. The contract manufacturing market in the United States is expected to reach $68.32 Billion USD by 2029.
Recent geo-political disruptions—from pandemic lockdowns to the changing administrations – have reinforced the value of domestic manufacturing infrastructure. As a result, CDMOs are seeing major capital investment from both biopharma sponsors and private equity, with new biologics facilities and advanced modality platforms under construction in states like North Carolina, Texas, and Ohio.
US Contract Development and Manufacturing Organizations
Here are key U.S.-based contract manufacturers, ranked by number of facilities in the country:
Charles River Laboratories is a global integrated CRO and CDMO partner dedicated to accelerating drug development with science-driven solutions. Charles River supports clients across the entire drug development continuum—from discovery and early research through to safety assessment, manufacturing, and commercialisation. With a foundation rooted in more than seven decades of scientific expertise, the company provides end-to-end services designed to streamline timelines and enhance efficiency. Its commitment to high-quality scientific outcomes is matched by a focus on ethical research practices and innovation in New Approach Methodologies (NAMs).
Number of facilities in the US: 25
Services: Analytical Development; Regulatory Services; Drug Substance (Biologics); Drug Substance (Cell & Gene); Process Development
Thermo Fisher Scientific’s Patheon is a Contract Development and Manufacturing Organisation (CDMO) that supports pharmaceutical and biotech companies throughout the drug development lifecycle. Leveraging deep scientific expertise and global manufacturing capabilities, Patheon enables clients to bring therapies to market efficiently and at scale. With operations integrated under Thermo Fisher Scientific, the company provides end-to-end services including early-phase development, clinical trial manufacturing, commercial production, and regulatory support.
Number of Facilities in the US: 19
Services: Regulatory Services; Solid Dosage; Packaging (Commercial); Clinical Packaging; Drug Substance (Biologics); Aseptic Fill Finish; Clinical Dosage; Drug Substance (Cell & Gene); Drug Substance (Small Molecule API); Analytical Development; Non Sterile Dosage; Process Development; Formulation Development; Drug Product Formulation (FDF)
Catalent is a leading Contract Development and Manufacturing Organisation (CDMO) that partners with pharmaceutical, biotechnology, and consumer health companies to bring innovative therapies and products to market efficiently and reliably. With expertise spanning biologics, small molecules, cell and gene therapies, and consumer health, Catalent delivers integrated solutions that streamline development, enhance product performance, and support global commercialisation.
Number of Facilities in the US: 17
Services: Regulatory Services; Drug Substance (Cell & Gene); Drug Substance (Biologics); Clinical Packaging; Analytical Development; Aseptic Fill Finish; Clinical Dosage; Packaging (Commercial); Solid Dosage; Process Development; Formulation Development; Drug Product Formulation (FDF)
Lonza, founded in 1897 in Switzerland and headquartered in Basel, is one of the world’s largest contract development and manufacturing organisations (CDMOs) serving the healthcare industry. Its business operates across four integrated platforms—Biologics, Small Molecules, Cell & Gene, and Capsules & Health Ingredients—spanning early discovery, process development, drug substance and product manufacturing, and dosage form innovation.
Number of Facilities in the US: 16
Services: Regulatory Services; Drug Substance (Small Molecule API); Drug Substance (Biologics); Drug Substance (Cell & Gene); Solid Dosage; Clinical Dosage; Packaging (Commercial); Clinical Packaging; Formulation Development; Drug Product Formulation (FDF)
Curia Global, formerly known as AMRI, is a leading CDMO that partners with pharmaceutical and biotech companies to accelerate the journey from discovery to commercial production. With an integrated suite of services covering research, development, and manufacturing, Curia supports the entire drug development lifecycle. The company combines scientific expertise with advanced technologies to deliver tailored solutions that meet clients’ timelines and quality expectations.
Number of facilities in the US: 12
Services: Drug Substance Manufacturing (API); Drug Product/FDF; Research & Development; Packaging(Commercial); Regulatory Services; Analytical Development; Process & Formulation Development.
Eurofins CDMO is part of the Eurofins BioPharma Services network and offers integrated development and manufacturing solutions to pharmaceutical and biotechnology companies worldwide. With a strong focus on flexibility, scientific rigour, and client partnership, Eurofins CDMO provides support across all stages of drug development — from preclinical to commercial production.
Number of facilities in the US: 11
Services: Regulatory Services; Analytical Development; Clinical Packaging; Clinical Dosage; Aseptic Fill Finish; Drug Substance (Biologics); Packaging (Commercial); Drug Substance (Cell & Gene); Solid Dosage; Non Sterile Dosage; Drug Substance (Small Molecule API); Process Development; Formulation Development; Drug Product Formulation (FDF)
Pfizer CentreOne is a leading CDMO that leverages decades of Pfizer’s manufacturing and scientific expertise to serve biopharmaceutical partners worldwide. As a distinct business within Pfizer, it combines the resources of a global pharmaceutical giant with a customer-focused, flexible service model tailored for contract manufacturing. With a strong heritage in complex compound production, sterile injectables, and oral solids, Pfizer CentreOne has built a reputation for reliability, regulatory excellence, and technical depth.
Number of facilities in the US: 11
Services: Regulatory Services;Aseptic Fill Finish;Packaging(Commercial);Drug Substance (Biologics);Clinical Dosage;Packaging (Clinical);Drug Substance (Small Molecule API);Solid Dosage;Drug Substance (Cell & Gene);Non Sterile Dosage;Analytical Development;Process & Forumulation Development;Process & Forumulation Development;Drug Product/FDF
PCI Pharma Services is a leading Contract Development and Manufacturing Organisation (CDMO) that partners with biopharma companies to accelerate the development and commercialisation of life-changing therapies. With more than 50 years of experience, PCI offers a comprehensive suite of services from early-phase development through to commercial launch, including formulation, manufacturing, clinical trial supply, and commercial packaging.
Number of facilities in the US: 9
Services: Regulatory Services; Packaging (Commercial); Clinical Packaging; Solid Dosage; Aseptic Fill Finish; Clinical Dosage; Analytical Development; Drug Substance (Small Molecule API); Non Sterile Dosage; Formulation Development; Drug Product Formulation (FDF)
Pace® Life Sciences offers comprehensive contract research and manufacturing solutions to accelerate the development and commercialisation of pharmaceutical and biopharmaceutical products. With a customer-focused approach and a strong regulatory track record, Pace® supports clients from preclinical development through to commercial manufacturing. Their integrated services are designed to reduce complexity, ensure compliance, and streamline the path from molecule to market.
Number of facilities in the US: 9
Services: Regulatory Services; Analytical Development; Clinical Dosage; Clinical Packaging; Formulation Development; Drug Substance (Small Molecule API); Drug Substance (Biologics)
Kindeva Drug Delivery is a Contract Development and Manufacturing Organisation (CDMO) with a focus on developing and producing complex drug delivery systems. With decades of experience rooted in innovation, Kindeva partners with pharmaceutical and biotech companies to bring combination products and delivery technologies from concept to commercialisation.
Number of facilities in the US: 8
Services: Regulatory Services; Solid Dosage; Non Sterile Dosage; Packaging (Commercial); Analytical Development; Aseptic Fill Finish; Drug Product Formulation (FDF)
Cambrex is a leading CDMO that provides comprehensive development and manufacturing solutions for small-molecule therapeutics. With more than 40 years of experience, Cambrex supports pharmaceutical and biotech partners across the entire drug lifecycle—from early-stage development through to commercial supply. The company operates a network of facilities across North America and Europe, offering scalable and flexible services tailored to client needs.
Number of Facilities in the US: 7
Services: Regulatory Services; Analytical Development; Drug Substance (Small Molecule API); Aseptic Fill Finish; Clinical Dosage; Packaging (Commercial); Clinical Packaging; Formulation Development; Drug Product Formulation (FDF)
AbbVie Contract Manufacturing is the CDMO division of AbbVie, a global biopharmaceutical company. With over 75 years of experience in pharmaceutical manufacturing, the organisation provides partners with access to AbbVie’s robust infrastructure, deep scientific know-how, and commitment to quality. Operating from a global network of facilities, AbbVie Contract Manufacturing offers end-to-end services across a broad range of technologies and therapeutic areas.
Number of facilities in the US: 6
Services: Regulatory Services; Solid Dosage; Packaging (Commercial); Aseptic Fill Finish; Non Sterile Dosage; Clinical Dosage; Drug Substance (Small Molecule API); Analytical Development; Drug Substance (Biologics); Clinical Packaging; Process Development; Formulation Development; Drug Product Formulation (FDF)
Alcami Alcami is a leading Contract Development and Manufacturing Organisation (CDMO) serving the pharmaceutical and biotechnology industries with fully integrated services from early-stage development through to commercial manufacturing. With decades of experience, Alcami provides tailored support across the drug lifecycle, helping clients accelerate timelines, ensure regulatory compliance, and deliver high-quality products to market.
Number of facilities in the US: 6
Services: Regulatory Services; Aseptic Fill Finish; Clinical Dosage; Packaging (Commercial); Clinical Packaging; Analytical Development; Solid Dosage; Formulation Development; Drug Product Formulation (FDF)
KBI Biopharma, a JSR Life Sciences company, is a leading biologics CDMO that partners with life sciences companies to accelerate the development and manufacture of innovative biologic therapies. With a global footprint and scientific expertise across development and manufacturing, KBI supports clients from preclinical stages through to commercialisation. The company operates facilities in the United States and Europe.
Number of Facilities in the US: 5
Services: Regulatory Services; Analytical Development; Drug Substance (Biologics); Drug Substance (Cell & Gene); Clinical Dosage; Process Development; Formulation Development
Fujifilm Biotechnologies is a contract development and manufacturing organisation (CDMO) specialising in the production of biologics, vaccines, and advanced therapies, including cell and gene therapies. Operating under the wider Fujifilm Group, the company offers end-to-end solutions from preclinical development through to commercial manufacturing.
Number of Facilities in the US: 5
Services: Regulatory Services; Drug Substance (Biologics); Aseptic Fill Finish; Clinical Dosage; Packaging (Commercial); Clinical Packaging; Drug Substance (Cell & Gene); Process Development; Formulation Development; Drug Product Formulation (FDF)
MilliporeSigma provides contract manufacturing services across the pharmaceutical value chain, offering customised solutions from active pharmaceutical ingredients (APIs) to final drug products. The company supports pharmaceutical and biotechnology firms with integrated, end-to-end solutions covering drug substance and drug product development. With expertise across a wide range of technologies and regulatory environments, the company delivers scalable, high-quality manufacturing tailored to client specifications.
Number of Facilities in the US: 5
Services: Regulatory Services; Drug Substance (Small Molecule API); Analytical Development; Drug Substance (Biologics); Packaging (Commercial); Drug Substance (Cell & Gene); Solid Dosage; Process Development; Formulation Development; Drug Product Formulation (FDF)
Grand River Aseptic Manufacturing (GRAM) is a leading US-based contract development and manufacturing organisation (CDMO) specialising in sterile injectable fill and finish services. The company provides advanced aseptic manufacturing solutions, supporting clients from clinical trials through to commercial production. GRAM’s growth is underpinned by its commitment to quality, regulatory compliance, and technological innovation.
Number of Facilities in the US: 5
Services: Aseptic Fill and finish;Packaging;Regulatory Services;Analytical Development
National Resilience, Inc. is a biomanufacturing company transforming the process of drug development and production. Founded with the mission to ensure the resilience of the biopharmaceutical supply chain, Resilience operates as a full-spectrum CDMO, offering flexible and scalable solutions for complex biologics, vaccines, nucleic acids, and cell and gene therapies. Its end-to-end platform leverages advanced manufacturing technologies, state-of-the-art facilities, and deep scientific expertise to support partners from early development through to commercial-scale production.
Number of Facilities in the US: 4
Services: Regulatory Services;Aseptic Fill Finish;Packaging(Commercial);Drug Substance (Biologics);Drug Substance (Cell & Gene);Clinical Dosage;Packaging (Clinical);Process & Forumulation Development;Process & Forumulation Development;Drug Product/FDF
Adare Pharma Solutions is a contract development and manufacturing organisation (CDMO) with deep expertise in oral drug delivery technologies. With decades of experience and a strong scientific foundation, Adare partners with pharmaceutical companies to solve complex formulation challenges and accelerate the development and commercialisation of novel therapies. Their work spans early-phase development to commercial-scale manufacturing, underpinned by proprietary technology platforms designed to enhance solubility, taste masking, and controlled release.
Number of Facilities in the US: 4
Services: Drug Product Formulation (FDF);Research & Development;Clinical Trials materials and logistics;Packaging;Regulatory Services;Analytical Development
Emergent BioSolutions is a global biopharmaceutical company specialising in medical countermeasures, vaccines, and treatments to support public health and biodefence. Emergent BioSolutions develops, manufactures, and commercialises protective and life‑saving products addressing public health threats and national security needs. Founded in 1998 and headquartered in Gaithersburg, Maryland, the company has grown through strategic partnerships and government contracts.
Number of Facilities in the US: 3
Services: Regulatory Services; Drug Substance (Biologics); Aseptic Fill Finish; Packaging (Commercial); Analytical Development; Drug Substance (Cell & Gene); Clinical Packaging; Non Sterile Dosage; Clinical Dosage; Process Development; Formulation Development; Drug Product Formulation (FDF)
Siegfried, founded in 1873 in Zofingen, Switzerland, by pharmacist Samuel Benoni Siegfried, has grown from a modest family‑run operation into a global CDMO powerhouse. With approximately 3,800–4,300 professionals across 13 sites on three continents—including Europe, North America, and Asia—it provides integrated development and manufacturing services for pharmaceutical companies.
Number of Facilities in the US: 3
Services: Regulatory Services; Drug Substance (Small Molecule API); Solid Dosage; Clinical Dosage; Packaging (Commercial); Analytical Development; Aseptic Fill Finish; Clinical Packaging; Formulation Development; Drug Product Formulation (FDF)
Bend Bioscience is a specialised CDMO committed to solving complex drug delivery challenges for the pharmaceutical and biotechnology industries. Based in Bend, Oregon, the company combines a deep scientific foundation with modern technology platforms to help accelerate the development of poorly soluble and challenging compounds. Their expertise spans early-phase development through to clinical supply, with a focus on improving the solubility, stability, and bioavailability of new chemical entities and existing molecules.
Number of Facilities in the US: 3
Services: Drug Product Formulation (FDF);Research & Development;Clinical Trials materials and logistics;Packaging;Regulatory Services;Analytical Development
Piramal Pharma Solutions (PPS) is the integrated Contract Development and Manufacturing Organisation (CDMO) arm of Piramal Pharma Limited, delivering a broad suite of services across the drug development and commercialisation value chain. With facilities located in North America, Europe, and Asia, PPS offers customers a global manufacturing footprint and a proven ability to support complex projects at all stages, from early development through to commercial supply.
Number of Facilities in the US: 3
Services: Regulatory Services;Drug Substance (Biologics);Analytical Development;Solid Dosage;Drug Substance (Small Molecule API);Aseptic Fill Finish;Clinical Dosage;Packaging(Commercial);Packaging (Clinical);Non Sterile Dosage;Process & Forumulation Development;Drug Product/FDF
AGC Biologics is a leading CDMO providing end-to-end development and manufacturing solutions for biologics and advanced therapies. With a global network of facilities across North America, Europe, and Asia, the company partners with pharmaceutical and biotechnology companies to accelerate the journey from preclinical development through to commercial production. AGC Biologics is known for its scientific excellence, flexible service models, and commitment to helping customers bring life-saving treatments to market.
Number of Facilities in the US: 3
Services: Drug Substance Manufacturing (API);Drug Product Formulation (FDF);Clinical Trials materials and logistics;Regulatory Services;Analytical Development
SK pharmteco is a global contract development and manufacturing organisation (CDMO) specialising in the production of active pharmaceutical ingredients (APIs) and intermediates for the pharmaceutical and biotechnology industries. SK pharmteco is a trusted partner for pharmaceutical and biotech companies, delivering high-quality API and intermediate manufacturing services across the globe.
Number of Facilities in the US: 3
Services: Regulatory Services;Drug Substance (Small Molecule API);Analytical Development;Drug Substance (Cell & Gene);Aseptic Fill Finish;Clinical Dosage;Packaging(Commercial);Packaging (Clinical);Process & Forumulation Development;Process & Forumulation Development;Drug Product/FDF
North American CDMO Landscape infographic
This infographic summarises the main players with facilities in North America who develop and manufacture Active Pharmaceutical Ingredients, Biologics, and Cell & Gene Therapies.
Download a free high-resolution infographic by filling out the short form, and let us know if you would like to see the separate infographic for US-based CDMOs.
